6-bromonaphthalene-2-carboxylic acid
6-bromo-2-naphthoic acid
CAS: 5773-80-8
Molecular Formula: C11H7BrO2
6-bromonaphthalene-2-carboxylic acid - Names and Identifiers
| Name | 6-bromo-2-naphthoic acid |
| Synonyms | ADAP-IMF 6-Bromo-2-naphthoicacid 6-bromo-2-naphthoic acid 6-BROMO-2-NAPHTHOIC ACID 6-BROMO-2-NAPHTHOLIC AICD 6-BROMO-2-NAPHTHOLIC ACID 6-Bromo-2-naphtalenecarboxylicacid 6-bromonaphthalene-2-carboxylic acid 6-bromo-2-Naphthalenecarboxylic acid 6-Bromonaphthalene-2-carboxylic acid 6-BROMO-2-NAPHTHALENE CARBOXYLIC ACID 2-naphthalenecarboxylic acid, 6-bromo- |
| CAS | 5773-80-8 |
| EINECS | 611-572-1 |
| InChI | InChI=1/C11H7BrO2/c12-10-4-3-7-5-9(11(13)14)2-1-8(7)6-10/h1-6H,(H,13,14) |
| InChIKey | NPMCAVBMOTZUPD-UHFFFAOYSA-N |
6-bromonaphthalene-2-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C11H7BrO2 |
| Molar Mass | 251.08 |
| Density | 1.648±0.06 g/cm3(Predicted) |
| Melting Point | 294-295°C |
| Boling Point | 387.3±17.0 °C(Predicted) |
| Flash Point | 188°C |
| Water Solubility | Insoluble in water. |
| Vapor Presure | 1.08E-06mmHg at 25°C |
| Appearance | White crystal |
| Color | White to Light yellow |
| BRN | 2328940 |
| pKa | 4.06±0.30(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.697 |
| MDL | MFCD01075720 |
| Physical and Chemical Properties | White crystalline powder. Melting point 294-295 °c. |
6-bromonaphthalene-2-carboxylic acid - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. |
6-bromonaphthalene-2-carboxylic acid - Reference Information
| Application | 6-bromo-2-naphthoic acid can be used as a pharmaceutical synthesis intermediate. Such as the preparation of Adapalene, Adapalene (Adapalene), is a naphthoic acid derivatives, is the third generation of vitamin A acid drugs, chemical name is 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid, an anti-acne drug developed by the French pharmaceutical company coderm. Adapalene is a kind of retinol compound that binds to the nuclear retinoic acid receptor with the same specificity as all-trans retinoic acid, the difference is that it selectively binds to retinoic acid receptor gamma, which is involved in keratinocyte proliferation and differentiation, and does not bind to cytoplasmic retinoic acid binding protein. Its mechanism of action is mainly through the regulation of hair follicle epithelial cell differentiation, reduce the formation of micro acne. |
| Use | for pharmaceutical intermediates |
Last Update：2024-04-09 02:00:09
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